To be honest, beating the Joker on Arkham Asylum was a pain in the arse. I needed one more grapple hook pull down thing, and then one of the guys who i hadn't killed before would come and punch me, and my chance was gone. Not difficult, just annoying. The End, as has been mentioned, in Snake Eater was difficult as well. And what a game that was, one of my favourites. In the old Street Fighters, I hated M Byson... that fucking whirlwind move and you were gone. I'm sure theres more, just can't think